NASA seeks to understand the nature of life in the universe and to assure astronaut health and productivity for increasing periods of time at greater distances beyond Earth.  NASA's interest in Microbial Genomics lies in the functional genomics of organisms in extreme environments, including the space environment.  While NASA does not develop fundamental genomic technologies, NASA investigators routinely use techniques including computational biology, bioinformatics, in-situ genomic analyses, medical genomics, and genomics as a basis for engineering.  NASA has a continuing interest in using the tools of genomics to enable correlation of environmental changes with changes in gene expression, gene products, metabolic effects, and structural changes over multiple generations.NASA seeks to understand the nature of life in the universe and to assure astronaut health and productivity for increasing periods of time at greater distances beyond Earth.  NASA's interest in Microbial Genomics lies in the functional genomics of organisms in extreme environments, including the space environment.  While NASA does not develop fundamental genomic technologies, NASA investigators routinely use techniques including computational biology, bioinformatics, in-situ genomic analyses, medical genomics, and genomics as a basis for engineering.  NASA has a continuing interest in using the tools of genomics to enable correlation of environmental changes with changes in gene expression, gene products, metabolic effects, and structural changes over multiple generations.